ИСПОЛЬЗОВАНИЕ ПРОПРАНОЛОЛА ДЛЯ ЛЕЧЕНИЯ ОСЛОЖНЕННЫХ ФОРМ ГЕМАНГИОМЫ У ДЕТЕЙ

Инфантильные гемангиомы (ИГ) ― наиболее распространенные опухоли, обнаруживаемые в раннем детстве, в том числе у 5−10% новорожденных. Несмотря на то, что при неосложненном течении болезни характерна спонтанная инволюция, ИГ требуют терапии с целью предотвращения обезображивания, функциональных нарушений или изъязвления. В 2008 г. был описан эффективный опыт лечения ИГ неселективным β-блокатором пропранололом. С этого момента было опубликовано более 200 статей, посвященных эффективности и безопасности β-блокаторов при лечении ИГ, а также оценке потенциальных побочных эффектов. В статье представлены литературные данные по оценке эффективности лечения гемангиом сложной локализации пропранололом на основании современных стандартов оказания медицинской помощи. Особое внимание уделено побочным эффектам, развивающимся при введении этого препарата. На основании результатов опубликованных научных работ β-блокаторы представляются весьма эффективными в лечении ИГ и имеют хороший профиль безопасности. Однако, для окончательного подтверждения  данного мнения необходимо продолжить проведение клинических исследований, создать достаточную доказательную базу.

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